WebAug 19, 2011 · Regioselective functionalization of the thiazole scaffold using TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl. A general method for the synthesis of 2,4,5-trisubstituted … So far not many structures of Turbo-Hauser bases are known. Generally, they show a complex temperature and concentration dependent behaviour in solution. This is why it is not easy to crystallize Hauser bases and their Turbo variants. The iPr-Turbo-Hauser base crystallizes as a dimeric amido bridged contact ion …
Selective functionalization of cyano-phenyl-2-oxazolines …
WebSep 1, 2011 · Thus, TMPMgCl·LiCl (17) which is readily prepared by the reacting of 2,2,6,6-tetramethylpiperidine with iPrMgCl·LiCl has a monomeric structure in solution as shown by García-Álvarez et al. [11]. It has excellent solubility in THF (1.2 M) and deprotonates positions in heterocycles otherwise difficult to metalate. WebNov 1, 2024 · The direct hydroxylation of 2-aryloxazolines via a deprotonative magnesiation using TMPMgCl·LiCl and subsequent oxidation with molecular oxygen or air as a green … bananen im angebot
Scaleable Preparation of Functionalized Organometallics
WebThe highly hindered amide base TMPMgCl•LiCl has been shown to effect efficient directed metallation of electron-poor heteroarenes and arenes containing sensitive functional … WebIntroduction. In the past decade, the direct functionalisation of inactivated C−H bonds has emerged as a powerful technique to access novel chemical entities. [1] Indeed, C−H functionalisation methods offer the opportunity to explore chemical space more effectively than relying solely on conventional synthetic approaches. [2] Late‐stage functionalization … WebMay 29, 2008 · Successive regio- and chemoselective magnesiations of pyrimidines using TMPMgCl·LiCl furnish, after trapping with various electrophiles, highly functionalized derivatives in good to excellent yields. Applications to the synthesis of antiviral and anti-inflammatory agents such as p38 and sPLA2 kinase inhibitors are reported. arterite de takayasu pdf