Cisplatin cystenyl glycine conjugate

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August undefined, 2024

WebMar 1, 2009 · In a series of papers, Hanigan and coauthors reported that the Pt-cysteine S-conjugate was converted to a toxic, highly reactive Pt-thiol by any of the several … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

Sodium selenite attenuated cisplatin-induced toxicity in rats: …

WebThis hypothesis was tested by pre-treating C57BL/6j mice with suramin prior to cisplatin. Our data indicates that suramin protects the kidney from injury by decreasing cisplatin-induced decreases in kidney function. Renal histology indicated that suramin significantly protected from cisplatin-induced AKI. Data indicate that suramin WebNational Center for Biotechnology Information flaherty lawn and tree

Cysteinylglycine C5H10N2O3S - PubChem

WebJan 24, 2024 · GSTs are able to conjugate glutathione (γ- l -glutamyl- l -cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs,... WebJan 30, 2024 · Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of malignancies due to its high efficacy and low cost. ... The resulting GSH-conjugates are cleaved into a cysteinyl-glycine-conjugate by gamma glutamyltranspeptidase which is localized on the surface of the kidney proximal tubule … WebMar 13, 2024 · Aminopeptidase N (APN) converts cysteinyl-glycine-conjugates into cysteine-conjugates which are, after entering into the PTECs, further metabolized to highly reactive and nephrotoxic thiols by enzymic activity of cysteine-S-conjugate beta-lyase (CCBL) [22, 44]. Having in mind that, among all tissues, GGT has the highest activity in … flaherty law firm great falls mt

Mei Deng University of Virginia Research contributor in ...

Cisplatin - an overview ScienceDirect Topics

WebJun 22, 2024 · The resultant substrate, a cisplatin-cysteinyl-glycine conjugate, is metabolized to cisplatin-cysteine by aminodipeptidase and reabsorbed into the proximal tubule cell . Subsequent metabolism processes in the proximal tubule cell lead to the development of a reactive thiol that enhances nephrotoxicity [ 12 ]. WebFeb 1, 2003 · Cisplatin-cysteine conjugates are suggested to be reabsorbed via renal cysteine heterodimeric amino acid transporters such as system-L, system-b0,+ or system … flaherty law great falls mtWebCisplatin is a potent antitumor agent currently used in the treatment of germ cell tumors, head and neck tumors, cervical cancer, and as a salvage treatment for other solid tumors … canon ts 6251

"WebMay 1, 2003 · Cisplatin cytotoxicity was judged by its antiproliferative action. Incubations with GSH were performed in the presence and in the absence of the dipeptide GlyGly (20 mM), added as an acceptor for the transpeptidation reaction [15] to replace the physiological acceptor cystine [18]. " - Cisplatin cystenyl glycine conjugate

Cisplatin cystenyl glycine conjugate

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WebNov 1, 2001 · The cysteine-conjugates are taken up into the cell and converted to a reactive thiol by either cysteine-conjugate β-lyase or S-oxidase. ... cisplatin-cysteinyl-glycine-conjugates, and cisplatin-cysteine-conjugates are all more toxic to proximal tubule cells than cisplatin. 25 We have also shown that inhibition of cysteine-conjugate β-lyase by ... WebFeb 16, 2024 · Cisplatin Pregnancy Warnings. Use is contraindicated. US FDA pregnancy category: Not assigned. `Risk Summary: Based on human data, this drug can cause fetal …

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Webwww.ncbi.nlm.nih.gov http://nopr.niscair.res.in/bitstream/123456789/12869/1/IJEB%2049(10)%20791-794.pdf

WebJun 1, 2003 · Search worldwide, life-sciences literature Search. Advanced Search E.g. "breast cancer" HER2 Smith J ... WebMei Deng is a academic researcher from University of Virginia. The author has contributed to research in topic(s): Nephrotoxicity & Conjugate. The author has an hindex of 3, co-authored 3 publication(s) receiving 322 citation(s). Previous affiliations of Mei Deng include Veterans Health Administration.

WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services. WebSep 8, 2024 · Cisplatin Glutathione conjugated cisplatin can be metabolized to a cysteinyl-glycine-conjugate, to a cysteine conjugate, and finally to a reactive thiol that is highly nephrotoxic . Alternatively, it is thought that glutathione conjugation, mediated by GSTA1, is a detoxification pathway responsible for cisplatin resistance in solid tumors ...

WebThe first step is the conjugation to glutathione, followed by the cleavage by GGT to a cysteinyl-glycine conjugate, the cleavage by aminopeptidase to a cysteine S …

WebAug 9, 2013 · The metabolism of the cisplatin-GSH to a cisplatin-cysteinyl-glycine conjugate is reduced by inhibiting GGT activity. A large number of sulfur-containing compounds, such as procainamide, diethyldithiocarbamate, N-methyl-D-glucamine dithiocarbamate, methimazole, sulfathiazole and the prodrug Amifostine, have been … canon ts6330 年賀状印刷WebAug 28, 2009 · Purpose The mechanisms for cisplatin-induced renal cell injury have been the focus of intense investigation for many years with a view to provide a more effective and convenient form of nephroprotection. BNP7787 (disodium 2,2′-dithio-bis ethane sulfonate; dimesna, Tavocept™), is a water-soluble disulfide investigational new drug that is … canon ts6200 ink numberWebCysteine Conjugate The S-cysteine conjugate of atrazine can rearrange to form an N-cysteine conjugate, and through a deamination process can form a postulated … flaherty law office great falls mtWebSep 18, 2024 · NCBI Bookshelf flaherty law firm west hartford ctWebStudies of placental DNA adducts have mainly focused on PAH-compounds (e.g. BP and its derivates) or AFB1, because they are metabolized by CYP1A1 found in human placenta. It remains to be studied whether any of the substrates of other CYP enzymes are metabolized in human placenta to reactive metabolites which form DNA adducts. flaherty law officeWebMetabolism of glutathione conjugate and the cystenyl-glycine conjugate occurs extracellularly, the cysteine conjugate metabolized intracellularly to reactive thiol by cysteine-S conjugate-lyase. The osmotic stress response could be affecting any of several steps in this pathway2, thus help to reverse the toxic effect of Cisplatin. flaherty law sarasota flaherty legal