Canrg1
WebNov 1, 2001 · The pathogenic fungus, Candida albicans contains homologues of the transcriptional repressors ScTup1, ScMig1 and ScNrg1 found in budding yeast. In … WebAug 1, 2002 · Inactivation of CaTup1 or CaNrg1 causes C. albicans to grow in filamentous forms. These mutants are less virulent 32••., 33•., superficially suggesting that hyphal cells are less invasive than yeast cells. However, there may be trivial explanations for such observations. For example, hyperfilamentous microcolonies may not be disseminated ...
Canrg1
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WebCaNrg1 contains a zinc finger domain that is conserved in transcriptional regulators from fungi to humans. It is most closely related to ScNrg1, which represses transcription in a … WebThe data revealed that CaNrg1 and CaTup1 regulate a different set of C. albicans genes from CaMig1 and CaTup1. This is consistent with the idea that CaMig1 and CaNrg1 …
WebSep 1, 2001 · CaNrg1 interacts specifically with an NRE in vitro. Also, deletion of two NREs from the ALS8 promoter releases it from Nrg1-mediated repression. Hence, CaNrg1 is a transcriptional repressor... WebHowever, CaMig1 and CaNrg1 repress other C. albicans genes in a CaTup1-independent fashion. The targets of CaMig1 and CaNrg1 repression, and phenotypic analyses of nrg1/nrg1 and mig1/mig1 mutants, indicate that these factors play differential roles in the regulation of metabolism, cellular morphogenesis and stress responses.
WebSep 1, 2001 · CaNrg1 interacts specifically with an NRE in vitro. Also, deletion of two NREs from the ALS8 promoter releases it from Nrg1-mediated repression. Hence, CaNrg1 is a …
WebNov 22, 2024 · Fts2 is not closely related in amino acid sequence to CaNrg1 and Rfg1, two major repressors of filamentation in C. albicans, yet it represses gene expression via the …
CaNrg1 contains a zinc finger domain that is conserved in transcriptional regulators from fungi to humans. It is most closely related to ScNrg1, which represses transcription in a Tup1-dependent fashion in Saccharomyces cerevisiae. dhr health directoryWebCaNrg1 interacts specifically with an NRE in vitro. Also, deletion of two NREs from the ALS8 promoter releases it from Nrg1-mediated repression. Hence, CaNrg1 is a transcriptional repressor that appears to target CaTup1 to a distinct set of virulence-related functions, including yeast-hypha morphogenesis. dhr health diabetesWebAug 23, 2002 · We discovered that deletion ofCaNRG1 had no discernible effect on the iron-responsive regulation of CaARN1, whereas deletion of RFG1resulted in loss of … cincinnati 19 weatherWebNov 1, 2024 · It is shown that mitochondrial inhibitors strongly decreased Ras1 GTP-binding and activity in C. albicans and similar effects were observed in other Candida species, suggesting a revised model for Ras1 and Cyr1 signaling in which Cyr1 and Ras1 influence each other and, together with Ira2, seem to form a master-regulatory complex necessary … cincinnati 2017 basketballWebSep 1, 2001 · CaNrg1 contains a zinc finger domain that is conserved in transcriptional regulators from fungi to humans. It is most closely related to ScNrg1, which represses transcription in a Tup1-dependent fashion in Saccharomyces cerevisiae. dhr health emailWebAlignment of the CaNrg1 C 2 H 2 domain (residues 226±286) from publication: EMBO J. 2001 Sep 3;20(17):4742-52. We have characterized CaNrg1 from Candida albicans, the major fungal pathogen in ... dhr health edinburg billingWebCaMig1, CaNrg1 and CaTup1 act mainly as repressors in C. albicans We predicted that CaMig1, CaNrg1 and CaTup1 might operate in C. albicans in a similar fashion to their counterparts in S. cerevisiae. It follows from this model that CaMig1, CaNrg1 and CaTup1 all act as repressors in C. albicans. dhr health healthstream