WebBMT CTN 0702 Protocol Number: BMT CTN 0702 Status: Open to Accrual Title: A trial of single autologous transplant with or without consolidation therapy versus tandem autologous transplant with lenalidomide maintenance Rationale: The study compares three different treatment strategies that combine high-dose therapy and WebThe benefit of Len maintenance in patients with high risk cytogenetics remains unclear and a focus has been on increasing post transplant interventions in this group of patients. Options include consolidation, allogeneic transplant, tandem autologous transplant. We have previously reported on BMT CTN 0102 a comparison of tandem autologous versus …
Blood & Marrow Transplant Clinical Trials Network BMT CTN
WebFeb 10, 2024 · Measuring response among patients with multiple myeloma is essential for the care of patients. Deeper responses are associated with better progression free survival (PFS) and overall survival (OS). To test the hypothesis that Mass-Fix, a mass spectrometry-based means to detect monoclonal proteins, i … WebContinued, Long-Term Follow-Up and Lenalidomide Maintenance Therapy for Patients Who Have Enrolled on BMT CTN 0702 BMT CTN 0702 Long-Term Follow-Up. Learn more. … i\u0027m ahead of the game
Mass-Fix better predicts for PFS and OS than standard methods
WebJan 17, 2024 · The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0702 trial (Clinicaltrials.gov identifier: NCT01109004) was a … To compare the use of tandem autologous hematopoietic cell transplantation (AHCT) followed by lenalidomide maintenance, AHCT plus four cycles of lenalidomide, bortezomib, and dexamethasone (RVD) followed by lenalidomide, and AHCT and lenalidomide only in improving outcomes for patients with active … See more At the time of this trial, initial myeloma reductive therapy followed by high-dose melphalan plus AHCT with long-term lenalidomide was the standard of care for patients newly diagnosed with multiple myeloma (MM) in the … See more Second AHCT or RVD consolidation as post-AHCT interventions for the up-front treatment of transplantation-eligible patients with multiple myeloma did not improve progression … See more Patients with symptomatic MM who were 70 years old or younger, had a Karnofsky score equal to or greater than 70 and who received at least two … See more The BMT CTN-0702 study was a Phase III multicenter trial. All patients were randomly assigned in a 1:1:1 manner at the time of enrollment, which occurred within 7 days before the first high-dose melphalan … See more WebNov 17, 2024 · Interestingly, the StaMINA trial, which was really an extension of the BMT CTN 0702 [trial], if you remember, initially they had patients who had a single transplant [who] were then randomized to either directly going to maintenance, a second transplant, a tandem transplant and then maintenance, or 4 cycles of VRd [bortezomib (Velcade ... i\u0027m a hedgehog not a cat